Wound healing compositions comprising biocompatible cellulose hydrogel membranes and methods of use thereof

A method of treating a wound in a subject in need thereof, said method comprising contacting the wound with an effective amount of a re-wet biocompatible cellulose hydrogel membrane, wherein

• the re-wet cellulose hydrogel membrane comprises one or more properties selected from the group consisting of:
• a cellulose content of from about 2% to about 9% by weight;
• a tensile strength of from about 50 kPa to about 600 kPa;
• a tear strength of from about 0.10 N/mm to about 0.60 N/mm;
• a strain to failure of from about 40% to about 80%;
• a suture retention strength of from about 0.05 N/mm to about 0.30 N/mm;
• a transparency that exceeds 85% at 550 nm (at 100 microns thickness);
• a Young's modulus of from about 100 kPa to about 700 kPa;
• and a puncture resistance of from about 50 kPa to about 300 kPa,
• the re-wet biocompatible cellulose hydrogel membrane comprises a composite comprising microcrystalline cellulose and bacterial cellulose,
• the re-wet biocompatible cellulose hydrogel membrane further comprises one or more microcrystalline cellulose layers and one or more bacterial cellulose layers,
• the one or more bacterial cellulose layers are oriented closer to the wound than the one or more microcrystalline cellulose layers, and
• the hydrogel membrane is in the shape of a contact lens.