Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

A low salt ophthalmic pharmaceutical composition comprising:

• a therapeutic lipid consisting essentially of castor oil at a concentration of about 0.25% (w/w);
• polysorbate 80 at a concentration of about 0.5% (w/w);
• acrylate/C10-C30 acrylate crosspolymer at a concentration of about 0.1% (w/w), wherein said acrylate/C10-C30 acrylate crosspolymer has a standard emulsion viscosity between 1,700 and 4,500 cPs;
• carboxymethylcellulose sodium at a concentration of about 0.5% (w/w);
• glycerin at a concentration of about 1.0% (w/w);
• a stabilized oxychloro complex preservative at a concentration of about 0.01% (w/w);
• boric acid at a concentration of about 0.6% (w/w);
• erythritol at a concentration of about 0.25% (w/w);
• levocarnitine at a concentration of about 0.25% (w/w);
• NaOH;
• and
• water.