Back to results
US 9,314,512 B2Granted
Treatment of synucleinopathies
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsMichael Schlossmacher, Lamya Shihabuddin, Seng H. Cheng, Valerie Cullen
Life of this patent
Estimating the term…
Abstract
This invention relates generally to treating synucleinopathies in subjects that are not clinically diagnosed with a lysosomal storage disease, as well as associated methods of making medicaments and screening methods.
Claims11
A method of treating a subject with a synucleinopathy, but not a clinically diagnosed lysosomal storage disease, the method comprising administering to a subject any one or more of:
- a cathepsin F polypeptide,
- a procathepsin F polypeptide, and
- a polynucleotide encoding a cathepsin F or procathepsin F polypeptide, in an amount effective to reduce a level of α-synuclein in the subject's nervous system, or in the subject's lysosomal compartment.
Dependencies are inferred from the claim text.