Bacteriocin derived from Lactobacillus rhamnosus
AssigneeHiroshima University
InventorHiroki Nikawa
Life of this patent
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Abstract
Provided is a bacteriocin that is capable of being easily mass-produced, has high antimicrobial activity even at low concentration, has a wide antimicrobial spectrum, and is less likely to produce resistant microorganisms. The bacteriocin has the amino acid sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2 in SEQUENCE LISTING, or has the same amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID NO: 2 in SEQUENCE LISTING except that one or several amino acids are deleted, substituted, inserted and/or added, wherein the amino acid sequence provides antimicrobial activity and the isoelectric point is not less than 12.
Claims11
A method for amelioration and/or therapy of diseases of the oral cavity caused by cariogenic bacteria, periodontal disease bacteria, and/or Candida, the method comprising:
- administering an isolated basic antimicrobial peptide comprising the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2, or a pharmaceutically acceptable salt of the basic antimicrobial peptide, to a subject with a disease of the oral cavity, wherein the basic antimicrobial peptide is antimicrobial to cariogenic bacteria, periodontal disease bacteria, and/or Candida.
A method for producing a basic antimicrobial peptide of SEQ ID NO:
- 1 or SEQ ID NO:
- 2, the method comprising:
- (a) culturing Lactobacillus rhamnosus and (b) extracting the basic antimicrobial peptide of SEQ ID NO:
- 1 or SEQ ID NO:
- 2 from the Lactobacillus rhamnosus of step (a).
Dependencies are inferred from the claim text.