US 9,314,497 B2Granted

E2F as a target of hormone refractory prostate cancer

AssigneeRutgers, The State University of New Jersey

InventorsJoseph R. Bertino, Debabrata Banerjee, Tamara Minko, Olga B. Garbuzenko, Xiaoqi Xie, John E. Kerrigan, Emine E. Abali, Kathleen W. Scotto

Life of this patent

Estimating the term…

Abstract

The instant invention provides amino acid sequences competing with E2F for DNA binding. Methods of using said amino acid sequences for treatment of hormone-refractory prostate cancer are also provided.

Claims8

Dependent claims

A method of treating a patient diagnosed with a blood cancer expressing E2F-1 comprising administering to the patient a peptide having an amino acid sequence consisting essentially of RQIKIWFQNRRIKWKKHHHRLSH (SEQ ID NO:

34).

Dependencies are inferred from the claim text.

Facts

Application: 14/474,595Filed 2 Sep 2014 · division
Priority: 14 Apr 2009
Published: US 2015/0202248 A123 Jul 2015
Granted: 19 Apr 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 38/16
Medicinal preparations containing peptides: peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 9/1271
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant: non-conventional liposomes,…
A61K 31/4436
Containing further heterocyclic ring systems: containing a heterocyclic ring having sulfur as a ring hetero atom
A61K 31/513
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine

Family

Application61/212,699Us provisional application · filed 14 Apr 2009
PCT/US2010/031098Parent of this continuation-in-part · filed 14 Apr 2010
Application13/274,118Parent of this division · filed 14 Oct 2011
US 2015/0202248 A1Pre-grant publication · published 23 Jul 2015
US 8,822,421 B2Parent of this division
Application13/274,118Parent of this continuation-in-part
US 2012/0093919 A1Published application
US 9,314,497 B2This patent

From the US filing history. Foreign family members aren’t listed.

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