Methods and compositions for cancer immunotherapy using flagellin-tumor associated antigen fusion protein expressing tumor cells
AssigneeIcahn School of Medicine at Mount Sinai
InventorsJulie Magarian Blander, Johan Garaude
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Abstract
Provided are methods for inducing an anti-tumor immune response by immunizing a mammal with a composition comprising a tumor cell which expresses a NLR ligand and/or TLR ligand-TAA fusion protein or with an activated DC which has internalized a tumor cell which expresses an NLR- and/or TLR ligand-TAA fusion protein.
Claims15
A composition comprising a dendritic cell (DC), wherein said DC has internalized a tumor cell expressing a fusion protein, said fusion protein comprising:
- a flagellin or fragment thereof and a tumor-associated antigen (TAA),
- wherein the flagellin or fragment thereof is capable of binding to one or more of Toll-like receptor-5 (TLR5), Naip5 or Ipaf.
A method for treating a cancer in a patient in need of such treatment comprising administering to said patient a composition comprising a tumor cell expressing a fusion protein, wherein said fusion protein comprises:
- a flagellin or fragment thereof and a tumor associated antigen (TAA), in an effective amount for eliciting an anti-tumor immune response,
- wherein the flagellin or fragment thereof is capable of binding to one or more of Toll-like receptor-5 (TLR5), Naip5 or Ipaf.
Dependencies are inferred from the claim text.