Compositions comprising rifabutin, clarithromycin, and clofazimine and uses thereof

A method of treating a subject suffering from a gastrointestinal disorder caused by a bacterial infection comprising:

• orally administering to the subject for an effective treatment period, a solid oral dosage form comprising:
• an effective amount of rifabutin;
• an effective amount of clarithromycin;
• an effective amount of clofazimine;
• an effective amount of an absorption enhancer, wherein the absorption enhancer is a polyethylene glycol, and the polyethylene glycol:
• (i) has an average molecular weight of between 1000-15000 Daltons, and (ii) is between 300% and 700% w/w relative to the amount of clofazamine;
• and
• a pharmaceutically acceptable carrier,
• wherein an amount of clofazimine is 10-15% w/w relative to an amount of clarithromycin and 20-25% w/w relative to an amount of rifabutin,
• wherein the effective treatment period is suitable to halt or reduce progression of the bacterial infection.