Chemokine receptor modulators

A method of treatment of a disorder associated with chemokine receptor activation in a patient in need of such treatment, comprising administering to the patient an effective amount of at least one compound elected from compounds of Formula I:

• wherein
• E is
• M is H or -G-L3-Z;
• L1, and L2, are each independently selected from the group consisting of a covalent bond, substituted or unsubstituted alkylene, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocycyl, and substituted or unsubstituted heterocyclyl;
• X, Y and Z are independently H, NRaRb, —ORc, halogen, CF3, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, acyl, carboxy, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted alkyl- or dialkylaminocarbonyl, cyano, optionally substituted heterocyclylacyl, optionally substituted carbocyclylacyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl;
• Ra and Rb are each independently selected from the group consisting of H, substituted or unsubstituted alkyl, aldiminyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted carbocyclylalkyl, substituted or unsubstituted heterocyclylalkyl, and substituted or unsubstituted heterocyclyl;
• or
• Ra and Rb, together with the nitrogen atom to which they are shown attached form a substituted or unsubstituted heterocyclyl;
• Rc is selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted carbocyclylalkyl, substituted or unsubstituted heterocyclylalkyl,
• Q is N;
• G is selected from the group consisting of a covalent bond, alkylene, —C(O)—, —C(O)—O—, and —C(O)—NRd—;
• Rd is selected from the group consisting of H, alkyl, and substituted or substituted arylalkyl;
• R3 and R4, taken together with the carbon atoms to which they are shown attached, form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• and
• A and B are each independently one or more substituents selected from the group consisting of H, alkyl, halo, substituted or unsubstituted amino, cyano, nitro, haloalkyl, hydroxyl, and alkoxyl;
• with the proviso that only one of M and L1X is H, and wherein the patient is in need of stem cell mobilization and selected from the group of patients defective in white blood cell count, immunosuppressed patients and patients in need of regeneration of cardiac tissue.