Styrenyl derivative compounds for treating ophthalmic diseases and disorders

A compound, or the pharmaceutically acceptable salt thereof, having a structure of Formula (A):

• wherein:
• R1 and R2 are hydrogen;
• R3, R4, R5 and R6 are each the same or different and independently hydrogen, halogen, —OR12, alkyl or fluoroalkyl;
• R7 and R8 are hydrogen;
• R9 is hydrogen;
• R10 is hydrogen;
• R11 is 5, 6-, or 7-member cycloalkyl;
• each R12 is independently selected from hydrogen or alkyl;
• Z is W—Y, wherein
• W is —C(R14)(R15)—;
• Y is —C(R16)(R17)—;
• R14 and R15 are each the same or different and independently hydrogen, halogen, alkyl, fluoroalkyl, —OR12, or —NR18R19;
• or R14 and R15 together form an oxo;
• R16 and R17 are each the same or different and independently hydrogen, halogen, alkyl, fluoroalkyl, —OR12, or —NR18R19;
• or R16 and R17 together form an oxo;
• and
• each R18 and R19 is independently selected from hydrogen or alkyl.