Methods of treating and preventing vascular instability diseases
AssigneeUniversity of Utah Research Foundation
InventorsChristopher C. Gibson, Dean Y. Li
Life of this patent
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Abstract
Methods are provided of treating and preventing stroke diseases, such as cerebral cavernous malformation, by the administration of tempol and/or cholecalciferol.
Claims20
A method of reducing a growth rate of a number of cerebral cavernous malformation (CCM) lesions in a patient having, or at risk of developing, at least one CCM lesion, the method comprising administering a therapeutically effective amount of tempol, a derivative thereof, or a pharmaceutically-acceptable salt of the foregoing.
A method of treating a sign or symptom of cerebral cavernous malformation (CCM) lesions in a patient having at least one CCM lesion, comprising administering a therapeutically effective amount of tempol, a derivative thereof, or a pharmaceutically acceptable salt thereof to the patient.
A method of decreasing cerebrovascular inflammation, reducing cerebrovascular permeability, or both, in a patient having at least one cerebral cavernous malformation (CCM) lesion, comprising administering a therapeutically effective amount of tempol, a derivative thereof, or a pharmaceutically acceptable salt thereof to the patient.
Dependencies are inferred from the claim text.