Antibacterial compounds
AssigneeSummit Therapeutics PLC
InventorsFrancis Xavier Wilson, Peter David Johnson, Richard Vickers, Richard Storer, Graham Michael Wynne, Alan Geoffrey Roach, Olivier De Moor, Colin Richard Dorgan, Paul James Davis
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Abstract
Disclosed are compounds of formula (I): which are of use in the treatment of bacterial diseases and infections, to compositions containing those compounds and to methods of treating bacterial diseases and infections using the compounds. In particular, the compounds are useful for the treatment of infection with, and diseases caused by, Clostridium difficile.
Claims3
A pharmaceutical composition comprising:
- a hydrate of the compound 2,2′-di(pyridin-4-yl)-1H, 1′H-5,5′-bibenzo[d]imidazole and a pharmaceutically acceptable excipient.
A method of treating Clostridium difficile-associated disease (CDAD) in a subject in need thereof, the CDAD selected from the group consisting of diarrhoea caused by Clostridium difficile, bloating caused by Clostridium difficile, flu-like symptoms caused by Clostridium difficile, fever caused by Clostridium difficile, appetite loss caused by Clostridium difficile, abdominal pain caused by Clostridium difficile, nausea caused by Clostridium difficile, dehydration caused by Clostridium difficile, colitis caused by Clostridium difficile and pseudomembraneous colitis caused by Clostridium difficile, which method comprises administering to said subject an effective amount of a hydrate of the compound 2,2′-di(pyridin-4-yl)-1H,1′H-5,5′-bibenzo[d]imidazole.
A composition comprising a hydrate of the compound 2,2′-di(pyridin-4-yl)-1H,1′H-5,5′-bibenzo[d]imidazole.
Dependencies are inferred from the claim text.