US 9,314,454 B2 · Oral cavity disintegrating tablet and method of producing the same

Abstract

The invention provides an orally disintegrating tablet containing (a) one or more saccharides or sugar alcohols selected from the group consisting of mannitol, lactose, xylitol, sucrose, erythritol and glucose and (b) low substituted hydroxypropylcellulose and substantially free of a starch disintegrant, which tablet is produced by steps of granulating a composition containing the above-mentioned components (a) and (b) by an agitation granulation method, and compression-molding the obtained granulation product. The invention also provides a method of producing an orally disintegrating tablet substantially free of a starch disintegrant, including steps of granulating a composition containing the above-mentioned components by an agitation granulation method, and compression-molding the obtained granulation product.

Claims6

Dependent claims

An orally disintegrating tablet comprising

(a) one or more saccharides or sugar alcohols selected from mannitol, lactose, xylitol, sucrose, erythritol and glucose,
(b) low substituted hydroxypropylcellulose, and
(c) 0.1-0.35 wt % powder hydrogenated maltose starch syrup,
wherein
the tablet is produced by steps of granulating a composition comprising components (a), (b), and (c) by an agitation granulation method, and compression-molding the obtained granulation product, and
the tablet is substantially free of a starch disintegrant.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/810,779Filed 26 Dec 2008

Priority

JP 2007-34070428 Dec 2007

Published

US 2010/0278930 A14 Nov 2010

Granted

19 Apr 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 31/4422
Non condensed pyridines; Hydrogenated derivatives thereof: 1,4-Dihydropyridines, e.g. nifedipine, nicardipine
A61K 9/0056
Mouth and digestive tract, i.e. intraoral and peroral administration: mouth soluble or dispersible forms; Suckable, eatable, chewable coherent…
A61K 9/2018
Organic compounds, e.g. phospholipids, fats: sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2054
Polysaccharides, e.g. alginate, gums; Cyclodextrin: cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Oral cavity disintegrating tablet and method of producing the same

Life of this patent

Oral cavity disintegrating tablet and method of producing the same

Life of this patent

Abstract

Claims6