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US 9,314,437 B2Granted
Pharmacologically optimized multimodal drug delivery system for nordihydroguiaretic acid (NDGA)
AssigneeNapo Pharmaceuticals, Inc.
InventorPravin R. Chaturvedi
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Abstract
The present invention relates generally to compositions and methods for oral delivery of nordihydroguaiaretic acid (NDGA). More particularly, the present invention relates to pharmacologically optimized multimodal drug delivery systems for orally administered NDGA and methods for preparation and use thereof.
Claims17
An orally administered single dose of nordihydroguiaretic acid (NDGA) for treating metabolic diseases, comprising:
- a multimodal drug delivery system defined by multimodal NDGA delivery kinetics, having
- a first portion of NDGA that is releasable at a peak pH of 1 to 4;
- a second portion of NDGA that is releasable at a peak pH of 5.0 to 7.5 , wherein over 30% of a total portion of NDGA present in the drug delivery system is present in the second portion;
- and
- wherein over 90% of the total portion of NDGA present in the drug delivery system is releasable at a pH of 7.5 or lower;
- wherein the structure of the NDGA comprised in the first portion or the second portion comprises Formula I:
3 more elements
An orally administered single dose of nordihydroguiaretic acid (NDGA) for treating metabolic diseases, comprising:
- a multimodal drug delivery system defined by multimodal NDGA delivery kinetics, having
- a first portion of NDGA that is releasable at a peak pH of 1 to 4 and contains over 10% of a total portion of NDGA present in the drug delivery system;
- a second portion of NDGA that is releasable at a peak pH of 5.0 to 7.5 and contains more than 30% of the total portion of NDGA present in the drug delivery system;
- and
- wherein over 90% of the total portion of NDGA present in the drug delivery system is releasable at a pH of 7.5 or lower;
- wherein the structure of the NDGA comprised in the first portion or the second portion is given by Formula I:
3 more elements
Dependencies are inferred from the claim text.