Solubilized benzoyl small molecule
AssigneeTransdermal Corp
InventorPankaj Modi
Life of this patent
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Abstract
The invention relates to a novel solubilized small molecule topical formulation for the transdermal delivery of small molecule agents comprising: a small molecule agent, one or more micelle forming compounds, one or more skin penetration enhancers, a surfactant, and one or more solvents, wherein the small molecule agent is solubilized in the solvent. The invention further relates to the use of the topical formulation as well as the process for making the topical formulation.
Claims41
A low temperature formed solubilized small molecule agent topical formulation comprising:
- small molecule agent in a concentration of between 1-10% by weight and not subjected to heating;
- one or more micelle forming compounds;
- one or more solvents maintained at 25 to 40 degrees C. selected from a group of pharmaceutically acceptable, organic solvents with a low dielectric constant, wherein said small molecule agent is substantially dissolved in the organic solvent with a low dielectric constant;
- one or more skin penetration enhancers maintained at 25 to 40 degrees C.;
- a surfactant maintained at 25 to 40 degrees C.;
- wherein said formulation is stable, at room temperature for a period in excess of four (4) weeks.
A process for the preparation of a solubilized small molecule agent topical formulation, said process comprising:
- a. Combining one or more micelle forming compounds, one or more penetration enhancers, one or more solvents and surfactant at 25 to 40° C. with constant stirring;
- b. Adding small molecule agent powder to the foregoing solution;
- and
- c. Cooling the resultant solution to room temperature.
A solubilized small molecule formulation comprising:
- a small molecule anti viral active agent;
- one or more micelle forming compounds
- one or more solvents;
- one or more skin penetration enhancers;
- and
- a surfactant.
A low temperature formed solubilized small molecule formulation comprising:
- small molecule antibiotic active agent in a concentration of between 1-10% by weight and not subjected to heating;
- one or more micelle forming compounds
- one or more solvents maintained at 25 to 40 degrees C. selected from a group of pharmaceutically acceptable, organic solvents with a low dielectric constant, wherein said small molecule antibiotic agent is substantially dissolved in the organic solvent with a low dielectric constant;
- one or more skin penetration enhancers maintained at 25 to 40 degrees C.;
- and
- a surfactant maintained at 25 to 40 degrees C.
- wherein said formulation is stable at room temperature for a period in excess of four (4) weeks.
A solubilized small molecule formulation comprising:
- a small molecule antifungal active agent;
- one or more micelle forming compounds
- one or more solvents;
- one or more skin penetration enhancers;
- and
- a surfactant.
A low temperature formed solubilized small molecule formulation comprising:
- a small molecule corticosteroid active agent in a concentration of between 1-10% by weight and not subjected to heating;
- one or more micelle forming compounds
- one or more solvents maintained at 25 to 40 degrees C. selected from a group of pharmaceutically acceptable, organic solvents with a low dielectric constant, wherein said small molecule corticosteroid active agent is substantially dissolved in the organic solvent with a low dielectric constant;
- one or more skin penetration enhancers maintained at 25 to 40 degrees C.;
- a surfactant maintained at 25 to 40 degrees C.;
- wherein said formulation is stable at room temperature for a period in excess of four (4) weeks.
Dependencies are inferred from the claim text.