Compositions and methods for the improvement of distance vision and the treatment of refractive errors of the eye

A method of treating a refractive error of the eye in a subject in need thereof comprising administering to a subject in need thereof a first composition comprising lyophilized aceclidine at a concentration from about 0.25% to about 2.5% w/v and a cryoprecipitate at a concentration from about 2.5% w/v to about 6.0% w/v and further comprising administering concurrently or sequentially a second composition comprising a cycloplegic agent at a concentration from about 0.025% to about 0.1% w/v and optionally one or more excipients selected from a nonionic surfactant at a concentration from about 0.25% to about 10% w/v, a viscosity enhancer, a buffer and a preservative, wherein w/v denotes weight by volume, wherein the refractive error of the eye is selected from presbyopia, myopia, hyperopia, astigmatism or a combination thereof.

A method for treating a refractive error of the eye comprising administering to a patient in need thereof a pharmaceutically acceptable amount of a composition comprising aceclidine at a concentration from about 0.25% to about 2.0% w/v and a cycloplegic agent at a concentration from about 0.025% to about 0.1% w/v, wherein w/v denotes weight by volume, wherein the size of the pupil is reduced to from about 1.5 to about 2.5 millimeters and wherein the refractive error is selected from the group consisting of corneal irregular astigmatism, an ectasia induced corneal irregularity, a pellucid induced corneal irregularity, a higher order aberration and a refractive surgery induced higher order aberration.