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US 9,314,421 B2Granted
Ultrasound-enhanced intrascleral delivery of macromolecules
AssigneeThe Hong Kong University of Science and Technology
InventorsYing Chau, Chi Yeung Cheung, Yu Yu
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Abstract
The present invention provides a novel system and method for transscleral delivery of therapeutic agents, including macromolecules, into a target site in intrascleral space using ultrasound. Advantageously, the present invention not only significantly enhances transscleral diffusivity of macromolecular therapeutic agents, but also causes little damages to ocular tissues and structure.
Claims19
An ultrasound-enhanced method for delivering one or more therapeutic agents to a target site in intrascleral space or across the sclera to intraocular tissue, comprising:
- a) providing an ultrasound-generating device and a well for transmitting ultrasound;
- b) positioning the ultrasound-generating device and the well so that ultrasound will be directed to a desired site of a sclera;
- c) generating ultrasound using the ultrasound-generating device and applying the ultrasound to the desired site of the sclera, wherein the ultrasound is applied at a frequency of about 20 kHz to about 100 kHz, wherein the ultrasound is applied at least once;
- and
- d) providing a therapeutic agent to the desired site of the sclera before, during, or after the ultrasound is applied;
- wherein said method delivers the therapeutic agent having a molecular weight of up to 150 k Dalton to a target site in intrascleral space or across the sclera to intraocular tissue.
3 more elements
Dependencies are inferred from the claim text.