Acellular bioabsorbable tissue regeneration matrices
OwnerJan-Eric Ahlforsinventor
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Abstract
The present invention provides methods and compositions useful in the regeneration of damaged, lost and/or degenerated tissue in humans and animals. In certain embodiments, the present invention provides an acellular bioabsorbable tissue regeneration matrix, methods of making such a matrix, and methods of using such a matrix for the regeneration of damaged, lost and/or degenerated tissue. In certain embodiments, methods and compositions of the present invention are useful in the treatment of damaged, lost and/or degenerated nerve tissue.
Claims21
An isolated acellular bioabsorbable tissue regeneration matrix derived from blood or bone marrow comprising a heterogeneous mixture of proteins and salts, wherein the overall protein content of the matrix is at least 1%, wherein the matrix is characterized by
- aggregates of spherical structures with a diameter of approximately at least 100 nm, wherein the acellular bioabsorbable tissue regeneration matrix lacks substantial metabolic activity as compared to that initially present in blood or bone marrow;
- and further wherein the acellular bioabsorbable tissue regeneration matrix is capable of initiating tissue regeneration in a subject with tissue damage, increasing tissue regeneration in a subject with tissue damage compared with untreated tissue, or both.
Dependencies are inferred from the claim text.