Compositions and methods for topical application and transdermal delivery of botulinum toxins
AssigneeRevance Therapeutics, Inc.
InventorsMichael D. Dake, Jacob M. Waugh
Life of this patent
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Abstract
Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health-related problems. Kits for administration are also described.
Claims37
A method of treating wrinkles, comprising:
- applying to an area of skin of a patient in need of treating wrinkles a formulation comprising:
- a botulinum toxin,
- a carrier comprising a positively charged polymeric backbone with positively charged efficiency groups covalently attached thereto,
- a poloxamer;
- and
- a dermatologically or pharmaceutically acceptable excipient, diluent, or medium;
- wherein the botulinum toxin is non-covalently associated with the positively charged backbone;
- and wherein the carrier comprising the positively charged backbone is the sole necessary agent for non-covalently associating with the botulinum toxin, and, optionally, applying an occlusion agent afterwards.
The method according to 1, wherein the botulinum toxin is of a serotype selected from the group consisting of serotypes A, B, C, D, E, F, G and mixtures thereof.
The method according to 16, wherein the botulinum toxin is of serotype A.
Dependencies are inferred from the claim text.