Device to measure pupillary light reflex in infants and toddlers

A method for acquiring pupillary light reflex information from a test subject that moving, said method comprising:

• disposing a test subject at least one-third of a meter from a remote tracking and imaging system and such that the test subject is free to move and rotate his/her head in any direction;
• continuously tracking, via a subject movement tracking camera of the remote tracking and imaging system, 3-dimensional and rotational movement of the test subject's head within a field of view of the subject movement tracking camera;
• acquiring, via the tracking of the movement of the test subject's head, subject eye location data regarding movement of a location of the subject's eyes within a field of view of the subject movement tracking camera while the test subject is at least one-third of a meter from the remote tracking and imaging system and free to move his/her head;
• acquiring, via at least one pupil data acquisition camera of the remote tracking and imaging system, high-resolution eye observation data while the test subject is at least one-third of a meter from the remote tracking and imaging system and free to move his/her head;
• continuously adjusting an angle of a plurality of scanning mirrors to maintain an on-axis line-of-sight of the pupil data acquisition camera(s) with subject's pupils as the subject moves his/her head while the test subject is at least one-third of a meter from the remote tracking and imaging system and free to move his/her head;
• selectively triggering, based on the eye observation data, an optical stimulation device of the remote tracking and imaging system to generate an optical stimulus light that causes a pupillary response of the test subject's eye while the test subject is at least one-third of a meter from the remote tracking and imaging system and free to move his/her head;
• acquiring, via the pupil data acquisition camera(s), high resolution pupil stimulus and response data regarding a response of the test subject's pupils to the optical stimulus light while the test subject is at least one-third of a meter from the remote tracking and imaging system and free to move his/her head;
• continuously recording the subject's head position and orientation, and eye gaze direction during the acquisition of the high resolution pupil stimulus and response data;
• computing, via a computer based system controller of the remote tracking and imaging system, pupillary light reflex (PLR) information based on the pupil stimulus and response data while the test subject is at least one-third of a meter from the remote tracking and imaging system and free to move his/her head;
• and
• correcting a measured pupil size based on subject's head position and orientation, and eye gaze direction.