Method and apparatus for detection of biological conditions
AssigneeToshiba America Electronic Components, Inc.
InventorRakesh Sethi
Life of this patent
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Abstract
A system and method for analysis of fluids, particularly bodily fluids such as saliva, uses an active, electrically-driven substrate for supporting an amalgamate of fluid and nanoparticles selected to adhere to one or more proteins. The nanoparticles affect light that is directed on or through the amalgamate. Different light directions, light polarization planes, and light wavelengths are used to obtain optical properties of the amalgamate. Once obtained, these values are compared to earlier or baseline values to determine a property of the amalgamate. Values or ranges are compared to earlier values, suitably with empirical association with maladies or conditions, to facilitate detection or diagnosis.
Claims19
A diagnostic device comprising:
- a memory configured to store baseline data corresponding to at least one optical baseline data acquisition;
- a substrate configured to receive a saliva/nanoparticle amalgamate;
- a light generator to direct light to the substrate to illuminate the amalgamate;
- a compound camera having a plurality of lenses configured to capture light from the amalgamate at multiple angles, the camera further configured to receive light from the light generator into each of the plurality of lenses after exposure to the amalgamate;
- the camera further configured to generate optical data corresponding to received light;
- a voltage generator configured to generate an electric field at the substrate;
- a comparator configured to generate comparison data corresponding to the optical data relative to stored baseline data;
- and
- an output configured to generate a signal in accordance with an output of the comparator.
A diagnostic device comprising:
- an active, electro-reactive substrate configured for receiving an amalgamate comprising a human saliva sample with electro-reactive nanoparticles;
- a light source configured over a temporal sweep over selected range of light wavelengths, the light source being directed to the amalgamate;
- a camera configured to capture light from the light source after exposure thereof to the amalgamate;
- an image data generator configured to generate image data corresponding to the captured light, which image data includes data corresponding to an angle of captured light;
- a comparator configured to generate comparison data in accordance with a comparison of image data relative to stored baseline data;
- and
- an output generator configured to generate an output signal corresponding to an output of the generator.
A diagnostic device comprising:
- a memory configured to store baseline data corresponding to at least one optical baseline data acquisition;
- a substrate configured to receive a saliva/nanoparticle amalgamate;
- a light generator to direct light to the substrate to illuminate the amalgamate;
- a compound camera having a plurality of lenses configured to capture light reflected from the amalgamate at multiple angles, the camera further configured to receive light from the light generator into each of the plurality of lenses after exposure to the amalgamate;
- the camera further configured to generate optical data corresponding to received light;
- a voltage generator configured to generate an electric field at the substrate;
- a comparator configured to generate comparison data corresponding to the optical data relative to stored baseline data;
- and
- an output configured to generate a signal in accordance with an output of the comparator.
Dependencies are inferred from the claim text.