Methods and apparatus for analyzing test data in determining the effect of drug treatments

A method, comprising:

• receiving pre-clinical data measured during drug treatment of a plurality of mammals including at least two treatment groups;
• performing at least one EXACT, non-parametric, statistical hypothesis test comparing the pre-clinical data for the at least two treatment groups;
• monitoring an amount of time elapsing during the performance of the EXACT, non-parametric, statistical hypothesis test on the pre-clinical data;
• determining whether the amount of time exceeds a predetermined threshold;
• completing the performance of the EXACT, non-parametric, statistical hypothesis test on the pre-clinical data when the determination is in the negative, and interrupting the performance of the EXACT, non-parametric, statistical hypothesis test on the pre-clinical data when the determination is in the affirmative;
• performing a Monte Carlo simulation method of statistical analysis on the pre-clinical data of at least one of the comparisons, if the determination is in the affirmative and the performance of the EXACT, non-parametric, statistical hypothesis test is interrupted;
• performing a Multiple Comparison Procedure (MCP) on the results of at least one of the EXACT, non-parametric, statistical hypothesis test and the Monte Carlo simulation method for at least two comparisons,
• wherein the EXACT, non-parametric, statistical hypothesis test, the Monte Carlo simulation method, and the MCP are conducted to produce one or more p-values, each p-value representing whether an associated one of the treatment groups has experienced a statistically significant improvement or decline in one or more conditions of the mammals associated with the treatment.

An apparatus, including a processor operating to perform actions in response to executing computer program instructions, and a non-transitory, computer-readable storage medium containing the computer program instructions, the actions comprising:

• receiving pre-clinical data measured during drug treatment of a plurality of mammals including at least two treatment groups;
• performing at least one EXACT, non-parametric, statistical hypothesis test comparing the pre-clinical data for the at least two treatment groups;
• and
• performing a Multiple Comparison Procedure (MCP) on a result of the EXACT, non-parametric, statistical hypothesis test for at least two comparisons,
• wherein the EXACT, non-parametric, statistical hypothesis test and the MCP are conducted to produce one or more p-values, each p-value representing whether an associated one of the treatment groups has experienced a statistically significant improvement or decline in one or more conditions of the mammals associated with the treatment.

An apparatus including a processor operating to perform actions in response to executing computer program instructions, and a non-transitory, computer-readable storage medium containing the computer program instructions, the actions comprising:

• receiving pre-clinical data measured during drug treatment of a plurality of mammals including at least two treatment groups;
• performing at least one EXACT, non-parametric, statistical hypothesis test comparing the pre-clinical data for the at least two treatment groups;
• monitoring an amount of time elapsing during the performance of the EXACT, non-parametric, statistical hypothesis test on the pre-clinical data;
• determining whether the amount of time exceeds a predetermined threshold;
• completing the performance of the EXACT, non-parametric, statistical hypothesis test on the pre-clinical data when the determination is in the negative, and interrupting the performance of the EXACT, non-parametric, statistical hypothesis test on the pre-clinical data of one or more comparisons when the determination is in the affirmative;
• performing a Monte Carlo simulation method of statistical analysis on the pre-clinical data of the one or more comparisons, if the determination is in the affirmative and the performance of the EXACT, non-parametric, statistical hypothesis test is interrupted;
• performing a Multiple Comparison Procedure (MCP) on results of at least one of the EXACT, non-parametric, statistical hypothesis test and the Monte Carlo simulation method for at least two comparisons,
• wherein the EXACT, non-parametric, statistical hypothesis test, or the Monte Carlo simulation method, and the MCP are conducted to produce one or more p-values, each p-value representing whether an associated one of the treatment groups has experienced a statistically significant improvement or decline in one or more conditions of the mammals associated with the treatment.