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US 9,310,371 B2Granted
Detection and treatment of cancer
AssigneeUniversity of Essex Enterprises Limited
InventorMetodi Vladimirov Metodiev
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Abstract
The present invention relates to a method for diagnosing, evaluating the prognosis of a cancer patient and evaluating the aggressiveness of a cancer. The methods comprise detecting the phosphorylation status of a Scribble protein, a fragment or variant thereof, wherein the phosphorylation status is indicative of cancer, prognosis and the aggressiveness of a cancer. In one embodiment the cancer is breast cancer.
Claims13
A method of treating cancer in a patient, the method comprising:
- detecting the phosphorylation status of one or more residues of a Scribble protein or fragment thereof, wherein the one or more residues are selected from the group consisting of S1306, S1309, S1348, and S1448 or a combination thereof;
- and
- administering a cancer treatment agent to the patient when said one or more residues of a Scribble protein or fragment thereof is unphosphorylated.
A method for treating a cancer patient, the method comprising:
- detecting the phosphorylation status of a Scribble protein of SEQ ID NO:
- 1, or fragment thereof, by
- obtaining a sample from a patient and contacting the sample with at least one antibody that is capable of specifically binding phosphorylated or unphosphorylated residues S1306, S1309, S1348 and S1448 or a combination thereof in the Scribble protein or fragment thereof;
- and
- administering to the patient a cancer treatment drug.
2 more elements
Dependencies are inferred from the claim text.