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US 9,310,362 B2Granted
Microwell array chip and method of manufacturing same
AssigneeValneva SE
InventorsAtsushi Muraguchi, Hiroyuki Kishi, Yoshiharu Tokimitsu, Sachiko Kondo, Tsutomu Obata, Satoshi Fujiki, Yoshiyuki Yokoyama, Hirofumi Nabesawa, Sotohiro Takabayashi, Katsumi Tanino
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Abstract
A microwell array chip made of silicon and having multiple microwells where each microwell is used to store a single specimen organic cell. The microwell of the array chip is of a size and shape to hold just one organic cell and the interior surface of the microwells are coated with a fluorocarbon film.
Claims6
A method of recovering a single specimen organic cell, which comprises:
- storing a single specimen organic cell in each microwell of a microwell array chip made of silicon and comprising multiple microwells;
- and
- individually recovering a stored single specimen organic cell from the microwell,
- wherein each microwell is of a size and shape holding just one organic cell,
- wherein the surface of said microwell array is covered by a film of silicon oxide,
- wherein the inner surface of said microwells is coated with a fluorocarbon film, so that the interior surface of said microwells prevents adhesion of the organic cell and facilitates recovery of the stored organic cell from the microwell, and
- wherein said single specimen organic cell is an antigen-specific B lymphocyte reacting to a specific antigen.
4 more elements
Dependencies are inferred from the claim text.