Nanofluidic sensor comprising spatially separated functional sensing components
AssigneeInternational Business Machines Corporation
InventorsJulia Baldauf, Stefan Harrer, Christine Schieber
Life of this patent
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Abstract
A method for making multiple single molecule receptors in a nanopore structure includes depositing a first material and a second material by a physical vapor deposition (PVD) technique onto different selected interior surfaces of a nanochannel and functionalizing a surface of the first material, the second material, or both the first and second materials with a chemical compound having at least two functional groups. The first and second materials can be the same or different and form patches having diameters of about 1 to about 100 nanometers (nm). Also disclosed are embodiments of a nanopore structure including multiple single molecule receptors.
Claims16
A method for making multiple single molecule receptors in a nanopore structure, the method comprising:
- depositing a first material and a second material by a physical vapor deposition (PVD) technique onto different selected interior surfaces of a nanochannel in the nanopore structure, the first and second materials being the same or different and forming patches having diameters of about 1 to about 100 nanometers (nm);
- and
- functionalizing a surface of the first material, the second material, or both the first and second materials with a chemical compound having at least two functional groups.
A method for making multiple single molecule receptors in a nanopore structure, the method comprising:
- tilting the nanopore structure at a first angle with respect to a beam to position the beam onto a selected interior surface of a nanochannel in the nanopore structure, the beam being operative to deposit materials by a PVD technique;
- operating the beam to deposit a first material onto a selected interior surface of the nano channel, the first material forming a first patch having a surface area of about 3 to about 10,000 nm2;
- re-tilting the nanopore to form a second angle with respect to the beam;
- operating the beam to deposit a second material onto another selected interior surface of the nanochannel and form a second patch, the first material and the second material being the same or different;
- and
- functionalizing a surface of the first patch, the second patch, or both the first and second patches.
A method for making multiple single molecule receptors in a nanopore structure, the method comprising:
- depositing a first material and a second material by a PVD technique onto different selected interior surfaces of a nanochannel of the nanopore structure, the first and second materials being the same or different and forming raised patches having diameters of about 1 to about 100 nm;
- and
- functionalizing a surface of the first material, the second material, or both the first and second materials with a chemical compound having at least two functional groups to form two single molecule receptors;
- wherein each of the two single molecule receptors is a binding site that binds to only a single molecule of an analyte in a complex sample.
Dependencies are inferred from the claim text.