US 9,309,572 B2 · Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms

Abstract

Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. The methods may include obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, using the information to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program, and developing a treatment plan for the subject to treat the disease or condition.

Claims9

Dependent claims

A method of predicting a trait in a subject, the method comprising:

obtaining a biological sample from the subject, wherein the subject is overweight or obese;
identifying by polymerase chain reaction (PCR) a nucleotide at a base position of an acid ceramidase polynucleotide sequence in the biological sample, wherein the base position is selected from the group consisting of:
rs2898458, rs7508, and rs3810, wherein the PCR is performed with a nucleic acid sequence selected from the group consisting of:
SEQ ID NO:3, SEQ ID NO:4, and SEQ ID NO:5, and wherein the nucleic acid sequence is labeled with a fluorophore;
and
predicting the expression of the trait in the subject based upon the identity of the nucleotide.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/318,768Filed 3 May 2010 · us provisional application

Priority

4 May 2009

Published

US 2012/0065080 A115 Mar 2012

Granted

12 Apr 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C12Q 1/6876
Involving nucleic acids: nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
C12Q 2600/124
Oligonucleotides characterized by their use: animal traits, i.e. production traits, including athletic performance or the like
C12Q 2600/156
Oligonucleotides characterized by their use: polymorphic or mutational markers
C12Q
Measuring or testing processes involving enzymes, nucleic acids or microorganisms

Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms

Life of this patent

Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms

Life of this patent

Abstract

Claims9