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US 9,309,550 B2Granted
Analyte sensors having nanostructured electrodes and methods for making and using them
AssigneeMedtronic MiniMed, Inc.
InventorsKenneth W. Cooper, Ratnakar Vejella, Gopikrishnan Soundararajan, Rajiv Shah
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Abstract
Embodiments of the invention provide analyte sensors having nanostructured electrodes as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a carbon nanotube electrode and a analyte limiting membrane that modulates the ability of a analyte to contact the carbon nanotube electrode.
Claims4
A method of sensing glucose within the body of a mammal, the method comprising implanting a glucose sensor into a mammal, wherein the glucose sensor comprises:
- a base layer;
- a conductive layer disposed upon the base layer wherein the conductive layer includes a working electrode comprising a plurality of conductive nanotubes;
- an analyte sensing layer comprising glucose oxidase disposed on the conductive nanotubes, wherein the glucose oxidase generates hydrogen peroxide in the presence of glucose;
- and
- an analyte modulating layer disposed on the analyte sensing layer, wherein the analyte modulating layer:
- modulates the diffusion of glucose therethrough;
- and
- includes a composition of matter comprising a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety;
- and
- sensing an alteration in electrical potential at the working electrode that results from hydrogen peroxide produced by the glucose oxidase in the presence of glucose;
- and correlating the alteration in electrical potential with the presence of glucose, so that glucose is sensed.
8 more elements
Dependencies are inferred from the claim text.