Recombinant virus-like particles encoded by multi-gene vector
AssigneePfizer Inc.
InventorsCorinne John, Christian Schaub, Sabine Wellnitz
Life of this patent
Estimating the term…
Abstract
The invention describes novel virus-like particles for use as vaccines, diagnostic tools and R&D tools based on recombinant DNA and cell cultivation techniques for production. The recombinant virus-like particles of the invention are assembled by polypeptide chains that incorporate several, in particular two or more, different epitopes which are selected either (a) from different viral strains of the same virus and/or (b) from different serotypes of the same virus and/or (c) from different viral strains specific for different hosts. These epitopes are then displayed on the particle surface.
Claims11
A single baculoviral vector encoding a recombinant virus-like particle comprising two or more different surface proteins comprising epitopes, wherein the surface proteins are selected from (a) different viral strains of a same virus type, (b) different serotypes of a same virus type, or (c) different viral strains of a same virus type specific for different hosts;
- and wherein the baculoviral vector comprises a polynucleotide sequence selected from SEQ ID NOs:1 to 5.
Dependencies are inferred from the claim text.