Gene therapy composition for use in diabetes treatment
AssigneeUniversidad Autonoma De Barcelona
InventorsFátima Bosch Tubert, Eduard Ayuso López, David Callejas Castiñeiras
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Abstract
New gene therapy constructions and compositions are the subject of present invention. The gene therapy compositions consist in adeno-associated vectors which jointly express insulin (Ins) and glucokinase (Gck) genes. The new gene therapy constructions are useful for treatment of diabetes either in dogs or human beings.
Claims6
Gene therapy composition which comprises a single vector carrying and allowing the expression of both an insulin gene (Ins) and a glucokinase gene (Gck) operatively linked, wherein the vector contains (i) the CDS of SEQ ID NO. 1 for the Ins gene and the CDS of SEQ ID NO. 4 for the Gck gene, (ii) the CDS of SEQ ID NO. 3 for the Ins gene and the CDS of SEQ ID NO. 4 for the Gck gene, or (iii) the CDS of SEQ ID NO. 3 for the Ins gene and the CDS of SEQ ID NO. 2 for the Gck gene.
Dependencies are inferred from the claim text.