Boronic and borinic acid compound as inhibitors of sulfenic acid-containing proteins

A method of inhibiting the biologic activity of a biologically-active sulfenic acid-containing enzyme that comprises the step of contacting said enzyme with an activity-inhibiting effective amount of a boronic acid or borinic acid compound of Formula V or a salt, hydrate, or solvate thereof, and maintaining that contact for a time sufficient to inhibit the activity of that enzyme

• wherein
• A is OR7,
• E is N, or CR2;
• G is N, or CR3;
• W is N, or CR4;
• X is N or CR5;
• Y is N or CR6;
• R* is R1 or OR1;
• R1 and R7 are selected independently from the group consisting of hydrido, optionally substituted C1-C8 hydrocarbyl, optionally substituted aryl, arC1-C8 hydrocarbyl, and optionally substituted heteroaryl, wherein said optional substituents are selected from the group consisting of C1-C8 hydrocarbyl, aryl, arC1-C8 hydrocarbyl, heteroaryl, heteroarC1-C8 hydrocarbyl, heterocyclyl, cyclohydrocarbyloxy, heterocyclyloxy, —C(O)-aryl, hydrocarbyloxy, aryloxy, heteroaryloxy, —OC(O)—(C1-C8 hydrocarbyl), —OCH2CH2OH, —O(CH2)3CO2H, 2-(morpholino)ethoxy, —(CH2)kOH (where k=1, 2 or 3), —CH2NH2, —CH2NH(C1-C8-hydrocarbyl), —CH2N(C1-C8 hydrocarbyl)2, halogen, formyl, thioformyl, —CH═NOH, —CO2H, thiocarboxyl, sulfonyl, C1-C8 hydrocarbyl-sulfonyl, arylsulfonyl, heteroarylsulfonyl, C1-C8-hydrocarbylsulfinyl, arylsulfinyl, heteroaryl-sulfinyl, —CO2(C1-C8-hydrocarbyl, —C(O)NH2, —C(O)NH(C1-C8-hydrocarbyl), —CON(C1-C8 hydrocarbyl)2, —OH, —SH, —S—(C1-C8-hydrocarbyl), —S-aryl, —SO2(C1-C8-hydrocarbyl), —SO2N(C1-C8-hydrocarbyl)2, C1-C8-hydrocarbyl-sulfonylamino, aryl-sulfonylamino, —SO2NH2, —SO3H, —SCF3, —CN, CHF2, —CF3, —NO2, amino, —NH(C1-C8-hydrocarbyl, —N(C1-C8-hydrocarbyl)2, arylamino, diarylamino, —NHSO2(C1-C8-hydrocarbyl), —C(O)NH(C1-C8-hydrocarbyl), and —C(O)N(C1-C8-hydrocarbyl)2;
• R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen (hydrido), C1-C8 hydrocarbyl, aryl, arC1-C8-hydrocarbyl, heteroaryl, heteroarC1-C8-hydrocarbyl, heterocyclyl, cyclohydrocarbyloxy, heterocyclyloxy, —C(O)-aryl, hydrocarbyloxy, aryloxy, heteroaryloxy, —OC(O)—(C1-C8-hydrocarbyl), —OCH2CH2OH, —O(CH2)3CO2H, 2-(morpholino)ethoxy, —(CH2)kOH (where k=1, 2 or 3), —CH2NH2, —CH2NH(C1-C8-hydrocarbyl), —CH2N(C1-C8 hydrocarbyl)2, halogen, formyl, thioformyl, —CH═NOH, —CO2H, thiocarboxyl, sulfonyl, C1-C8-hydrocarbyl-sulfonyl, arylsulfonyl, heteroarylsulfonyl, C1-C8-hydrocarbylsulfinyl, arylsulfinyl, heteroarylsulfinyl, —CO2(C1-C8-hydrocarbyl), —C(O)NH2, —C(O)NH(C1-C8-hydrocarbyl), —CON(C1-C8-hydrocarbyl)2, —OH, —SH, —S—(C1-C8-hydrocarbyl), —S-aryl, —SO2(C1-C8-hydrocarbyl), —SO2N(C1-C8-hydrocarbyl)2, C1-C8-hydrocarbyl-sulfonylamino, aryl-sulfonylamino, —SO2NH2, —SO3H, —SCF3, —CN, —CHF2, —CF3, —NO2, amino, —NH(C1-C8-hydrocarbyl), —N(C1-C8-hydrocarbyl)2, arylamino, diarylamino, —NHSO2(C1-C8-hydrocarbyl), —CONH(C1-C8-hydrocarbyl), and —C(O)N(C1-C8-hydrocarbyl)2, wherein said C1-C8-hydrocarbyl, aryl, arC1-C8 hydrocarbyl, heteroaryl, heteroarC1-C8-hydrocarbyl, cyclohydrocarbyl and heterocyclic groups in each of the R2, R3, R4, R5 and R6 (R2-6) substituents are themselves optionally substituted and wherein said optional substituents are selected from the group consisting of C1-C8-hydrocarbyl, aryl, arC1-C8-hydrocarbyl, heteroaryl, heteroarC1-C8-hydrocarbyl, heterocyclyl, cyclohydrocarbyloxy, heterocyclyloxy, —C(O)-aryl, hydrocarbyloxy, aryloxy, heteroaryloxy, —OC(O)—(C1-C8-hydrocarbyl), —OCH2CH2OH, —O(CH2)3CO2H, 2-(morpholino)ethoxy, —(CH2)kOH (where k=1, 2 or 3), —CH2NH2, —CH2NH(C1-C8-hydrocarbyl), —CH2N(C1-C8-hydrocarbyl)2, halogen, formyl, thioformyl, —CH═NOH, —CO2H, thiocarboxyl, sulfonyl, C1-C8-hydrocarbyl-sulfonyl, arylsulfonyl, heteroarylsulfonyl, C1-C8-hydrocarbylsulfinyl, arylsulfinyl, heteroaryl-sulfinyl, —CO2(C1-C8 hydrocarbyl, —C(O)NH2, —C(O)NH(C1-C8-hydrocarbyl), —CON(C1-C8-hydrocarbyl)2, —OH, —SH, —S—(C1-C8-hydrocarbyl), —S-aryl, —SO2(C1-C8-hydrocarbyl), —SO2N(C1-C8-hydrocarbyl)2, C1-C8-hydrocarbylsulfonylamino, aryl sulfonylamino, —SO2NH2, —SO3H, —SCF3, —CN, —CHF2, —CF3, —NO2, amino, —NH(C1-C8-hydrocarbyl, —N(C1-C8-hydrocarbyl)2, arylamino, diarylamino, —NHSO2(C1-C8hydrocarbyl), —C(O)NH(C1-C8-hydrocarbyl), and —C(O)N(C1-C8-hydrocarbyl)2.