Salmonella enterica presenting C. jejuni N-glycan or derivatives thereof
AssigneeEidgenoessische Technische Hochschule Zurich
InventorsKarin Ilg, Markus Aebi, Umesh Ahuja, Saba Amber, Flavio Schwarz
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Abstract
The present invention relates to Salmonella enterica comprising at least one pgl operon of Campylobacter jejuni or a functional derivative thereof and presenting at least one N-glycan of Campylobacter jejuni or N-glycan derivative thereof on its cell surface. In addition, it is directed to medical uses and pharmaceutical compositions thereof as well as methods for treating and/or preventing Campylobacter and optionally Salmonella infections and methods for producing these Salmonella strains.
Claims14
Salmonella enterica, comprising at least one pgl operon of Campylobacter jejuni and further comprising at least one N-glycan of Campylobacter jejuni on its cell surface, wherein one or more genes for bacillosamine biosynthesis are inactivated by mutation or partial or complete deletion.
Dependencies are inferred from the claim text.