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US 9,309,409 B2Granted
Polymethine compounds and their use as fluorescent labels
AssigneeIllumina Cambridge Limited
InventorsXiaohai Liu, Nikolai Nikolaevich Romanov
Life of this patent
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Abstract
The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
Claims17
A compound of formula (I) or mesomeric forms thereof:
- wherein mCat+ or mAn− is an organic or inorganic positively/negatively charged counterion and
- m is an integer 0-3;
- n is an integer 1-5;
- Rf represents OH or O−;
- or an ester or amine conjugate linked to a substrate moiety;
- each of Ra1 and Ra2 is independently H, SO3−, sulfonamide, halogen, or a further ring fused to an adjacent carbon atom;
- wherein either Ra1 or Ra2 is sulphonamide or SO3−;
- and
- each of Rc1 and Rc2 is independently alkyl or substituted alkyl;
- wherein when Ra1 or Ra2 is SO3−, either i) Rc1 or Rc2 is an alkyl sulfonic acid group, or ii) Ra1 or Ra2 is a sulphonamide.
7 more elements
Dependencies are inferred from the claim text.