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US 9,309,325 B2Granted
Antibodies and methods of use thereof
AssigneeThe Regents of the University of California
InventorsCharles S. Craik, Eric L. Schneider
Life of this patent
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Abstract
The disclosure relates to protease-binding agent specific for a protease. The agent may be an antibody capable of specifically binding and inhibiting a protease, such as a P1-Arg-specific protease. The disclosure also provides methods of producing, and compositions comprising the subject agent. Methods and kits related to the protease-binding agent find use in protection against, detection, diagnosing, treating cancer and infections due to pathogens containing active proteases.
Claims16
A protease-binding antibody, comprising:
- a) a VLCDR1 comprising the amino acid sequence of SEQ ID NO:
- 16;
- b) a VLCDR2 comprising the amino acid sequence of SEQ ID NO:
- 17;
- c) a VLCDR3 comprising the amino acid sequence of SEQ ID NO:
- 18;
- d) a VHCDR1 comprising the amino acid sequence of SEQ ID NO:
- 19;
- e) a VHCDR2 comprising the amino acid sequence of SEQ ID NO:
- 20;
- and
- f) a VHCDR3 comprising the amino acid sequence of SEQ ID NO:
- 10.
10 more elements
Dependencies are inferred from the claim text.