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US 9,309,323 B2Granted
Methods for detecting and treating cancer
AssigneeThe University of British Columbia
InventorsDavid Huntsman, Helen Merkens, Aruna Somasiri, Kelly M. McNagny, Calvin Roskelley
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Abstract
Methods and kits for detecting cancer and monitoring cancer progression are described. The method involves analyzing a sample containing nucleic acids or proteins from a patient for decreased expression of endoglycan and/or increased expression of podocalyxin.
Claims4
A method of inhibiting cancer metastasis or treating cancer having a poor outcome comprising:
- (i) obtaining a sample from an animal;
- (ii) measuring the expression level of podocalyxin peptide in said sample;
- (iii) comparing the expression level of (ii) to a control,
- (iv) identifying the animal as having, or having a risk of metastatic cancer or cancer having a poor outcome if the animal overexpresses the podocalyxin polypeptide compared to the control;
- and
- (v) administering an effective amount of an agent that modulates the podocalyxin polypeptide to the animal having, or having a risk of metastatic cancer or cancer having a poor outcome;
- wherein the agent that modulates the podocalyxin polypeptide is a podocalyxin antagonist comprising an antibody that binds the podocalyxin polypeptide.
4 more elements
Dependencies are inferred from the claim text.