Therapy with CD4 binding peptides and radiation
AssigneeGenmab A/S
InventorsPaul Parren, Ole Baadsgaard, Denis Alexander
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Abstract
The present invention relates to a peptide, such as an antibody, capable of binding to CD4 and use thereof for the mediation of radiation treatment of a clinical condition. The radiation treatment may for instance by treatment with PUVA.
Claims34
A method of treatment of a CD4+ T-cell lymphoma comprising administering to a subject in need thereof a therapeutically effective amount of an antibody, or antigen-binding fragment thereof, comprising heavy and light chain variable region sequences as set forth in SEQ ID NOs:
- 1 and 2, respectively, and radiation treatment, wherein the radiation treatment is selected from the group consisting of psoralen and long-wave ultraviolet radiation (PUVA):
- UVB;
- narrow band UVB;
- high dose UVA;
- electron beam;
- x-ray;
- and photopheresis, wherein the psoralen is a photosensitizer.
A method of mediating radiation treatment of a CD4+ T-cell lymphoma comprising administering to a subject in need thereof a therapeutically effective amount of an antibody, or antigen-binding fragment thereof, comprising heavy and light chain variable region sequences as set forth in SEQ ID NOs:
- 1 and 2, respectively, and radiation treatment, wherein the radiation treatment is selected from the group consisting of psoralen and long-wave ultraviolet radiation (PUVA);
- UVB narrow band UVB;
- high dose UVA;
- electron beam;
- x-ray;
- and photopheresis, wherein the psoralen is a photosensitizer.
Dependencies are inferred from the claim text.