Anti-ADDL monoclonal antibody and uses thereof
AssigneeMerck Sharp & Dohme Corp.
InventorsRenee C. Gaspar, Paul J. Shughrue, Fubao Wang, Weirong Wang, Ningyan Zhang, Wei-Qin Zhao, Min Xu, Alexander McCampbell
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Abstract
The present invention relates to antibodies that bind amyloid β-derived diffusible ligands, also known as ADDLs. The antibodies of the invention are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs.
Claims10
An isolated antibody, or an antigen binding fragment thereof, that binds amyloid β-derived diffusible ligands, said antibody or fragment comprising:
- (a) a light chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:1,
- (ii) a CDR2 of SEQ ID NO:2,
- (iii) a CDR3 of SEQ ID NO:10;
- and
- (b) a heavy chain variable region comprising,
- (i) a CDR1 of SEQ ID NO:4,
- (ii) a CDR2 of SEQ ID NO:5, and
- (iii) a CDR3 of SEQ ID NO:6.
Dependencies are inferred from the claim text.