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US 9,309,305 B2Granted
Anti-ricin antibodies and uses thereof
AssigneeNational Research Council of Canada
InventorsWei-Gang Hu, Laurel M Negrych, Damon Chau, Junfei Yin, Scott J. Jager, John W. Cherwonogrodzky
Life of this patent
Estimating the term…
Abstract
The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments thereof as well as their use in therapy or prophylaxis.
Claims6
An isolated or purified antibody or fragment thereof comprising a variable chain comprising a CDR L1 of sequence KASQDVTAAVA (SEQ ID NO:4), a CDR L2 of sequence SASYRYT (SEQ ID NO:8), and a CDR L3 of sequence QQYYNTPLT (SEQ ID NO:12);
- and a variable heavy chain comprising CDR H1 of sequence EHIIN (SEQ ID NO:16), a CDR H2 of sequence LINPNSGGTNYNQKFKD (SEQ ID NO:20), and a CDR H3 of sequence LRYDAAY (SEQ ID NO:24), wherein the isolated or purified antibody or fragment thereof specifically binds ricin toxin lectin-B protein.
Dependencies are inferred from the claim text.