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US 9,309,287 B2Granted
Inhibitors of TLR signaling by targeting TIR domain interfaces
AssigneeUniversity of Maryland, Baltimore
InventorVladimir Toshchakov
Life of this patent
Estimating the term…
Abstract
TIR-domain decoy peptides and TIR domain peptides are disclosed, as well as methods of using the peptides in the regulation of toll-like receptor (TLR) activation and signaling.
Claims2
A TIR-derived decoy peptide selected from the group consisting of:
- TRAP based, TIR-derived decoy peptides
- TR3 (RQIKIWFQNRRMKWKKEGSQASLRCF;
- SEQ ID NO:1),
- TR5 (RQIKIWFQNRRMKWKKELCQALSRSHCR;
- SEQ ID NO:2),
- TR6 (RQIKIWFQNRRMKWKKPGFLRDPWCKYQML;
- SEQ ID NO:3),
- TR9 (RQIKIWFQNRRMKWKKAAYPPELRFMYYVD;
- SEQ ID NO:4),
- TR11 (RQIKIWFQNRRMKWKKGGFYQVKEAVIHY;
- SEQ ID NO:5),
- TRAM based, TIR-derived decoy peptides
- TM4-ΔC (RQIKIWFQNRRMKWKKIVFAEMPCG;
- SEQ ID NO:7),
- TM6 (RQIKIWFQNRRMKWKKENFLRDTWCNFQFY;
- SEQ ID NO:8),
- TRIF based, TIR-derived decoy peptides
- TF5 (RQIKIWFQNRRMKWKKCLQDAIDHSGFT;
- SEQ ID NO:10),
- TF5-ΔC (RQIKIWFQNRRMKWKKCLQDAIDHS;
- SEQ ID NO:11),
- MyD88 based, TIR-derived decoy peptides
- M3 (RQIKIWFQNRRMKWKKEQTDYRLKLC;
- SEQ ID NO:12),
- M5 (RQIKIWFQNRRMKWKKIASELIEKRCRRM;
- SEQ ID NO:14),
- TLR2 based, TIR-derived decoy peptides
- 2R1 (RQIKIWFQNRRMKWKKRKPKKAPCRDVCYD;
- SEQ ID NO:20),
- 2R3 (RQIKIWFQNRRMKWKKENSDPPFKLC;
- SEQ ID NO:21),
- 2R9 (RQIKIWFQNRRMKWKKPQRFCKLRKIMNT;
- SEQ ID NO:22),
- and
- 2DD-αD (RQIKIWFQNRRMKWKKEPIERKAIPQRFCK;
- SEQ ID NO:24), and variants thereof having one or two amino acid changes, independently selected from additions, substitutions and deletions, in the TIR-domain segment of the peptide.
33 more elements
A TIR-derived decoy peptide selected from the group consisting of:
- TIRAP based, TIR-derived decoy peptides
- TR3 (RQIKIWFQNRRMKWKKEGSQASLRCF;
- SEQ ID NO:
- 1),
- TR5 (RQIKIWFQNRRMKWKKELCQALSRSHCR;
- SEQ ID NO:2),
- TR6 (RQIKIWFQNRRMKWKKPGFLRDPWCKYQML;
- SEQ ID NO:3),
- TR9 (RQIKIWFQNRRMKWKKAAYPPELRFMYYVD;
- SEQ ID NO:4),
- TR11 (RQIKIWFQNRRMKWKKGGFYQVKEAVIHY;
- SEQ ID NO:5),
- TRAM based, TIR-derived decoy peptides
- TM4-ΔC (RQIKIWFQNRRMKWKKIVFAEMPCG;
- SEQ ID NO:7),
- TM6 (RQIKIWFQNRRMKWKKENFLRDTWCNFQFY;
- SEQ ID NO:8),
- TRIF based, TIR-derived decoy peptides
- TF5 (RQIKIWFQNRRMKWKKCLQDAIDHSGFT;
- SEQ ID NO:
- 10),
- TF5-ΔC (RQIKIWFQNRRMKWKKCLQDAIDHS;
- SEQ ID NO:
- 11),
- MyD88 based, TIR-derived decoy peptides
- M3 (RQIKIWFQNRRMKWKKEQTDYRLKLC;
- SEQ ID NO:
- 12),
- M5 (RQIKIWFQNRRMKWKKIASELIEKRCRRM;
- SEQ ID NO:
- 14),
- TLR2 based, TIR-derived decoy peptides
- 2R1 (RQIK1WFQNRRMKWKKRKPKKAPCRDVCYD;
- SEQ ID NO:20),
- 2R3 (RQIK1WFQNRRMKWKKENSDPPFKLC;
- SEQ ID NO:21),
- 2R9 (RQIK1WFQNRRMKWKKPQRFCKLRKIMNT;
- SEQ ID NO:22), and
- 2DD-αD (RQIKIWFQNRRMKWKKEPIERKAIPQRFCK;
- SEQ ID NO:24).
37 more elements
Dependencies are inferred from the claim text.