Compositions and methods for augmenting permeability barriers
AssigneeTufts Medical Center, Inc.
InventorUsamah S. Kayyali
Life of this patent
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Abstract
Compositions and methods for activating MK2, augmenting permeability barriers, such as epithelial and/or endothelial barriers, and treating diseases, conditions, disorders, and/or injuries associated therewith, such as pulmonary edema and other lung diseases and injuries are provided herein.
Claims12
A peptide comprising a transduction domain and a domain that blocks an autoinhibitory domain of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2), wherein the amino acid sequence of said peptide is at least 90% identical to YARAAARQARAHPRNPARRTPGTRRGAPAA (SEQ ID NO:8), YARKARRQARRHPRNPARRTPGTRRGAPAA (SEQ ID NO:9), YGRKKRRQRHPRNPARRTPGTRRGAPAA (SEQ ID NO:10), YGRKKRRQRRRHPRNPARRTPGTRRGAPAA (SEQ ID NO:11), GRKKRRQRRRPPQCHPRNPARRTPGTRRGAPAA (SEQ ID NO:12), or RRRRRRRRRHPRNPARRTPGTRRGAPAA (SEQ ID NO:13).
A method of activating MK2 in a subject comprising administering to the subject a peptide comprising a transduction domain and a domain that blocks an autoinhibitory domain of MK2, wherein the amino acid sequence of said peptide is at least 90% identical to YARAAARQARAHPRNPARRTPGTRRGAPAA (SEQ ID NO:8), YARKARRQARRHPRNPARRTPGTRRGAPAA (SEQ ID NO:9), YGRKKRRQRHPRNPARRTPGTRRGAPAA (SEQ ID NO:10), YGRKKRRQRRRHPRNPARRTPGTRRGAPAA (SEQ ID NO:11), GRKKRRQRRRPPQCHPRNPARRTPGTRRGAPAA (SEQ ID NO:12), or RRRRRRRRRHPRNPARRTPGTRRGAPAA (SEQ ID NO:13).
Dependencies are inferred from the claim text.