Method for modification of organic molecules
AssigneeNanyang Technological University
InventorsChuan-Fa Liu, Fupeng Li
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Abstract
The present invention is directed to a method of alkylating a thiol group (R—S—H) or seleno group (R—Se—H) in a target molecule wherein the method comprises: reacting a target molecule comprising at least one thiol group with a compound of formula (I) or (II): wherein R is an acetyl group or any other acyl group or is a group comprising any one of: or wherein R in formula (II) can also be an alkyl group; and wherein R′ is selected from a group consisting of a hydrogen, a methyl group and an ethyl group. In certain cases, the described methods may be used to install acetylated lysine analogs in target molecules (e.g., peptides, proteins).
Claims18
A method of alkylating a thiol group or a seleno group in a target molecule, the method comprising:
- a thiol-ene reaction comprising reacting said thiol or seleno group with a compound of formula (I) or (II):
- Wherein:
- R is an acetyl group, an acyl group (other than acetyl), a poly(ethylene glycol)-containing acyl group (“PEG-containing acyl group”) or is selected from the group consisting of:
- R1 is an alkyl group, an acyl group, PEG, or a PEG-containing acyl group;
- and
- R′ is selected from the group consisting of a hydrogen, a methyl group and an ethyl group.
Dependencies are inferred from the claim text.