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US 9,309,276 B2Granted
Synthetic lipid A derivative
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorGeert-Jan Boons
Life of this patent
Estimating the term…
Abstract
The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.
Claims15
A compound having formula I:
- wherein:
- R1 is an anomeric protecting group;
- R2 is azido;
- R3 is H or allyloxycarbonate (Alloc);
- R4 is a hydroxyl protecting group;
- R5 is —NHR11, wherein R11 is fluorenylmethoxycarbamate (Fmoc) or 2,2,2-trichloroethoxycarbonyl (Troc);
- R6 is H, allyloxycarbonate (Alloc) or levulinate (Lev);
- provided that when R6 is H, R3 is allyloxycarbonate (Alloc);
- and
- R7 and R8 are each independently H, a phosphate, a substituted phosphate, a hydroxyl protecting group, or together form a ring.
7 more elements
A compound having formula I:
- wherein:
- R1 is an anomeric protecting group;
- R2 is azido;
- R3 is H or allyloxycarbonate (Alloc);
- R4 is a hydroxyl protecting group;
- R5 is —NHR11, wherein R11 is fluorenylmethoxycarbamate (Fmoc) or 2,2,2-trichloroethoxycarbonyl (Troc);
- R6 is acyl;
- and
- R7 and R8 are each independently H, a phosphate, a substituted phosphate, a hydroxyl protecting group, or together form a ring.
6 more elements
Dependencies are inferred from the claim text.