Metalloenzyme inhibitor compounds
AssigneeViamet Pharmaceuticals, Inc.
InventorsWilliam J. Hoekstra, Christopher M. Yates
Life of this patent
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Abstract
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Claims21
A compound of formula (I) or salt thereof, wherein:
- R1 is halo;
- R2 is halo;
- each R3 is independently cyano, haloalkyl, alkoxy, haloalkoxy, hydroxy, amino, —NR6R9, —SR10, —C(O)R10, optionally substituted haloalkyl, optionally substituted arylalkoxy, —C(O)NR6R7, —CH(OH)-haloalkyl, optionally substituted alkyl, hydroxyalkyl, alkoxyalkyl, isocyano, cycloalkylaminocarbonyl, optionally substituted aryloxyalkyl, optionally substituted arylalkylthio, haloalkylthio, optionally substituted arylalkylsulfonyl, optionally substituted arylalkylsulfinyl, optionally substituted heteroarylalkoxy, optionally substituted arylthioalkyl, or haloalkylcarbonyl;
- n is 0, 1, 2 or 3;
- R4 is aryl optionally substituted with 0, 1, 2 or 3 independent R8;
- R5 is H, alkyl, phosphato, phosphito, alkoxyphosphato, or —C(O)alkyl optionally substituted with 1 or 2 amino;
- R6 is independently H or alkyl;
- R7 is independently H, optionally substituted alkyl, optionally substituted haloalkyl, or optionally substituted arylalkyl;
- each R8 is independently cyano, haloalkyl, alkoxy, halo, or haloalkoxy;
- each R9 is independently H, alkyl, —C(O)alkyl, —C(O)H, —C(O)haloalkyl, optionally substituted arylalkyl, or optionally substituted haloalkyl;
- each R10 is independently H, optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocycloalkyl, or optionally substituted arylalkyl;
- Ar2 is
- R11 is phenyl, alkyl, thienyl, pyrrolyl, furanyl, pyridyl, —CH(OH)-alkyl, —CH(OH)-haloalkyl, arylalkyl, aryloxyalkyl, haloalkyl, haloalkoxyalkyl, indolyl, benzofuranyl, heterocycloalkyl, or
- R12 is R4, —C(O)R4, —C(O)RD, —SO2R4;
- MBG is optionally substituted tetrazolyl, optionally substituted triazolyl, optionally substituted oxazolyl, optionally substituted pyrimidinyl, optionally substituted thiazolyl, or optionally substituted pyrazolyl.
A compound that is 4-((4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)ethynyl)phenoxy)methyl)benzonitrile (8), or salt thereof.
A compound that is 4-((4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl) propyl)pyridin-3-yl) ethynyl) phenoxy)methyl)-2-fluorobenzonitrile (7), or salt thereof.
Dependencies are inferred from the claim text.