Spirooxindole derivative and process for producing the same

A compound of formula I:

• wherein
• R1 is hydrogen, halogen;
• lower alkyl, lower cycloalkyl, lower alkenyl, lower alkynyl, lower alkoxy wherein these substituents are optionally substituted with halogen;
• cyano, nitro;
• hydroxyl optionally protected with an appropriate protective group;
• amino optionally protected with an appropriate protective group,
• aryl, heteroaryl wherein these substituents are optionally substituted with
• halogen;
• lower alkyl, lower alkoxy wherein these substituents are optionally substituted with halogen;
• or
• cyano;
• —C(═O )ORa, —C(═O)NRaRb, —OC(═O)Ra, —OC(═O)ORa, —OC(═O)NRaRb, —NHC(═O)NRaRb, —N{C(═O)Ra} {C(═O)Rb};
• Ra and Rb are each independently hydrogen;
• lower alkyl, lower cycloalkyl, lower alkenyl, lower alkynyl wherein these substituents are optionally substituted with halogen;
• Ra and Rb together form —(CH2)1—, or
• Ra and Rb taken together with the nitrogen atom to which they are attached, form heteroaryl
• R2 is, each independently, hydrogen, halogen, hydroxyl;
• lower alkyl, lower alkoxy wherein these substituents are optionally substituted with halogen,
• R3 is hydrogen;
• lower alkyl, lower cycloalkyl wherein these substituents are optionally substituted with halogen or oxo;
• lower alkyl-sulfonyl, aryl-sulfonyl;
• N-protecting group;
• aryl, heteroaryl wherein these substituents are optionally substituted with alkyl, alkoxy, halogen, or hydroxyl;
• R4 and R5 are each independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, hydroxyl optionally protected with an appropriate protective group, or amino optionally protected with an appropriate protective group, —NRaRb,
• R4 and R5 taken together with the carbon atom to which they are attached, form carbonyl (C═O), oxime (C═NORc), hydrazone (C═N—NRcRd), acetal (C(ORc)ORd),
• Rc and Rd, are each independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, N-protecting group, or O-protecting group;
• n is 0 to 12,
• m is 0 to 4,
• l is 2 to 8
• or racemate, enantiomer, diastereomer, mixture thereof, or pharmaceutically acceptable salt thereof.