Azaindolines

A compound of Formula I:

• wherein:
• W is selected from the group
• a) H,
• b) C1-6-alkyl that optionally includes 1-3 deuterium atoms, and
• c) C1-6-alkyl that optionally may be substituted with SO2R5 and OR5;
• Y is C1-6-alkyl that optionally may be substituted with OR5;
• Z is N;
• R1 is selected from the group
• a) C1-6-alkyl that optionally may be substituted with SO2R5,
• b) C3-7-cycloalkyl,
• c) heterocyclyl, and
• d) aryl;
• R2 is selected from the group
• a) H
• b) C(O)NHR6,
• c) heterocyclyl, and
• d) heteroaryl;
• R3 and R4 may be the same or different and each is independently selected from the group
• a) H, and
• b) C1-6-alkyl;
• R5 is selected from the group
• a) H,
• b) C1-6-alkyl,
• c) NR7R8, and
• d) aryl;
• R6 is selected from the group
• a) H,
• b) aryl that optionally may be substituted with C1-6-alkyl, OR5, halogen, C(O)OR5, C(O)NR7R8, aryl, heterocyclyl, C(O)R9, SO2R5, cyano and CF3,
• c) C1-6-alkyl that optionally may be substituted with CF3, SO2R5 and aryl that optionally may be substituted with C1-6-alkyl and halogen,
• d) heteroaryl that optionally may be substituted with C1-6-alkyl, OR5, halogen, aryl and oxo, and
• e) heterocyclyl;
• R7 and R8 may be the same or different and each is independently selected from the group
• a) H,
• b) C1-6-alkyl, and
• c) aryl;
• R9 is selected from the group
• a) C1-6-alkyl, and
• b) aryl;
• or a pharmaceutically acceptable salt thereof.