Back to results
US 9,309,247 B2Granted
2-substituted imidazo[4,5-D]phenanthroline derivatives and their use in the treatment of cancer
AssigneeLorus Therapeutics Inc.
InventorsYoon Lee, Howard Cukier, Venkata Nedunuri, Robert Peralta, Mario Huesca, Aiping H. Young
Life of this patent
Estimating the term…
Abstract
The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumor cells or non-small cell lung cancer cells.
Claims27
A compound of formula (I):
- or a salt or solvate thereof, wherein:
- between C and X, and between C and Y designates a single or a double bond, and at least one of is a single bond;
- X is optionally substituted alkoxy or NR3R4 when between C and X is single bond, or
- X is O when between C and X is a double bond;
- Y is N when between C and Y is a double bond, or Y is NH, when between C and Y is a single bond;
- R1 and R2 are independently H, optionally substituted alkyl, or optionally substituted alkoxy, and
- R3 and R4 are taken together to form a 5 or 6 membered optionally substituted heterocycle, having at least one heteroatom that is N or O;
- and
- provided that when X is O and between C and X is a double bond;
- then R1 and R2 both are not H.
7 more elements
Dependencies are inferred from the claim text.