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US 9,309,237 B2Granted
HIV inhibitors
AssigneesNew York Blood Center, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsAsim Kumar Debnath, Francesca Curreli, Peter D. Kwong, Young Do Kwon
Life of this patent
Estimating the term…
Abstract
Chemical compounds that inhibit retroviruses are presented herein. More particularly, this disclosure provides small molecule compounds that inhibit infection with, or treat infection caused by, human immunodeficiency viruses.
Claims6
A pharmaceutical composition comprising a compound represented by a formula:
- wherein Ph1 is phenyl optionally substituted with 1 or 2 substituents or cycloheptyl optionally substituted with 1 or 2 substituents, wherein each substituent is independently F, Cl, Br, RC, ORC, CORC, or RC—OH, wherein each RC is independently C1-6 alkyl;
- Rt is a bond or C1-3 alkyl;
- Ar1 is thiazolyl, pyridinyl, or phenyl optionally substituted with 1 or 2 substituents, wherein each substituent is independently F, Cl, Br, RC, ORC, CORC, or RC—OH, wherein each RC is independently C1-6 alkyl;
- and
- Cy1 is piperidinyl, pyrrolidinyl, azepanyl, piperazinyl, or morpholino, optionally substituted with 1, 2, 3, or 4 substituents, wherein each substituent is independently F, Cl, Br, RC, ORC, CORC, or RC—OH, wherein each RC is independently C1-6 alkyl;
- and b is 0 or 1.
3 more elements
Dependencies are inferred from the claim text.