US 9,309,236 B2 · PI-kinase inhibitors with broad spectrum anti-infective activity

Abstract

Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.

Claims11

Dependent claims

A compound of the structure:

wherein:
R1 is selected from an aryl, a heterocycle, and a cycloalkyl;
R2 is selected from hydrogen, a halogen, an alkyl and an alkoxy;
R3 is an alkyl;
R4 is an alkyl, an alkyl-cycloalkyl, or an alkyl-heterocyclyl;
W1 is —SO2—;
and
W2 is —NHCO—.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/348,864Filed 5 Oct 2012 · us provisional application

Priority

5 Oct 2011

Published

US 2015/0051193 A119 Feb 2015

Granted

12 Apr 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07D 417/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 277/40
Nitrogen atoms: unsubstituted amino or imino radicals
C07D 277/42
Nitrogen atoms: amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
C07D 277/44
Nitrogen atoms: acylated amino or imino radicals

PI-kinase inhibitors with broad spectrum anti-infective activity

Life of this patent

PI-kinase inhibitors with broad spectrum anti-infective activity

Life of this patent

Abstract

Claims11