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US 9,309,228 B2Granted
Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as a medicament and the preparation thereof
AssigneeBoehringer Ingelheim International GmbH
InventorsMarkus Ostermeier, Peter Sieger
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Abstract
The present invention relates to a compound of formula (I), which has valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, processes for stereoselectively preparing these compounds, particularly pharmaceutical formulations suitable for inhalation and their use for the treatment of diseases, particularly tumoral diseases, benign prostatic hyperplasia and diseases of the lungs and airways.
Claims11
A compound of formula (I)
- wherein n denotes the number 1.5,
- characterized in that reflections in the X-ray powder diagram occur at dhkl values of 17.13, 4.55, 3.46 and 3.20 Å,
- optionally in the form of the tautomers thereof.
Dependencies are inferred from the claim text.