N-biphenylmethylbenzimidazole modulators of PPARG

A non-agonist PPARG modulatory compound of formula (IA) or a pharmaceutically acceptable salt thereof:

• wherein:
• R2 is H or (C1-C4)alkyl;
• R3 is optionally mono- or multi-substituted aryl or arylalkyl,
• wherein if present each substituent on R3 is independently selected from the group consisting of (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C3-C9)cycloalkyl, halo, haloalkyl, haloalkoxy, nitro, cyano, CO2R′, methylenedioxy, OR′, N(R′)2, (C1-C4)alkyl-S(O)q, SO2NR′2, and (C1-C6)alkoxyl,
• wherein R′ is independently H, (C1-C6)alkyl, (C1-C6)haloalkyl, or (C3-C9)cycloalkyl,
• or wherein two R′ bonded to an atom together with the atom form a 3-8 membered ring
• and wherein alkyl, alkenyl, alkynyl, aryl, arylalkyl, or cycloalkyl is optionally mono- or independently multi-substituted with (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, halo, OR′, N(R′)2, aryl, or aroyl;
• and wherein an alkyl or an alkyl group of a cycloalkylalkyl or arylalkyl can be substituted with oxo;
• each X1-X4 is independently C substituted with an independently selected Z, provided that there is one and only one Z group present in the ring comprising X1,
• Z is a group of formula
• wherein a wavy line indicates a point of attachment,
• each X5-X7 is independently C substituted with an independently selected H or R4;
• R4 is H, halo, CO2R′, CN, OR′, N(R′)2, (C1-C4)alkyl optionally mono- or multi-substituted with halo, OR′ or N(R′)2 or a combination thereof, R′S(O)2NHC(O), R′C(O)NHS(O)2, or (C1-C4)alkyl-S(O)q—;
• or R4 is —(C(R′)2)mCO2R′ or is —O(C(R′)2)mCO2R′, wherein m is 1, 2, or 3;
• R is H or (C1-C6)alkyl;
• q is 0, 1 or 2;
• R5 is H or (C1-C4)alkyl;
• R6 is R7;
• or R5 and R6 taken together form a —CH2CH2— group;
• and,
• R7 is H, halo, CO2R′, CN, OR′, N(R′)2, (C1-C4)alkyl or (C1-C4)fluoroalkyl optionally substituted with OR′ or N(R′)2, or (C1-C4)alkyl-S(O)q;
• or R7 is —(C(R′)2)mCO2R′ or is —O(C(R′)2)mCO2R′, wherein m is 1, 2, or 3.