1-substituted indazole derivative

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof
• wherein
• A is CR1E,
• X—Y—Z is N—CO—NR3AR3B or N—CO—R4,
• R1A is a C1-6 alkyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkoxy, a C3-6 cycloalkyl, —NR6R7, —CONR6R7 and —NR6COR7;
• a C3-10 cycloalkyl or a 4- to 10-membered saturated heterocycle, wherein the cycloalkyl and the saturated heterocycle are optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy and —NR6R7;
• a C1-6 alkoxy optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkoxy, —NR6R7, —CONR6R7 and —NR6COR7;
• a hydrogen atom;
• a halogen;
• —NR6R7;
• a cyano group;
• —CONR6R7;
• —NR6COR7;
• or —SO2R6, provided that both R6 and R7 are not a hydrogen atom,
• R1B to R1E are each independently a C1-6 alkyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkoxy, a C3-6 cycloalkyl, —NR6′R7′, —CONR6′R7′ and —NR6′COR7′;
• a C3-10 cycloalkyl or a 4- to 10-membered saturated heterocycle, wherein the cycloalkyl and the saturated heterocycle are optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy, —NR6′R7′, —CONR6′R7′ and —NR6′COR7′;
• a C1-6 alkoxy or a C3-10 cycloalkoxy, wherein the alkoxy and the cycloalkoxy are optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkoxy, —CONR6′R7′ and —NR6′COR7′;
• a hydrogen atom;
• a hydroxy group;
• a halogen;
• an aryl or a heteroaryl, wherein the aryl and the heteroaryl are optionally substituted with 1 to 5 substituents independently selected from the group consisting of a halogen, a hydroxy group, a C1-6 alkyl optionally substituted with 1 to 5 fluorine atoms, a C1-6 alkoxy, —NR6′R7′, —CONR6′R7′ and —NR6′COR7′;
• —NR6′R7′;
• a cyano group;
• —CONR6′R7′;
• —NR6′COR7′;
• or —SO2R6′, provided that both R6′ and R7′ are not a hydrogen atom,
• R2A to R2D are each independently a C1-6 alkyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of a halogen, a hydroxy group, a C1-6 alkoxy and —NR8R9;
• a hydrogen atom;
• a halogen;
• a hydroxy group;
• or a C1-6 alkoxy optionally substituted with 1 to 5 fluorine atoms, or when two of R2A to R2D are a C1-6 alkyl, they may be taken together to form a 4- to 10-membered saturated carbocyclic ring optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy and —NR8R9,
• R3A, R3B and R4 are each independently a C1-10 alkyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of phenyl, a monocyclic heteroaryl, a 4- to 10-membered saturated heterocycle, a C3-10 cycloalkyl, a fluorine atom, a hydroxy group, a C1-6 alkoxy optionally substituted with 1 to 5 fluorine atoms, and —NR10R11;
• a C3-10 cycloalkyl;
• a 4- to 10-membered saturated heterocycle;
• phenyl;
• a monocyclic heteroaryl;
• or a hydrogen atom, wherein the cycloalkyl, the saturated heterocycle, the phenyl and the monocyclic heteroaryl may be optionally substituted with 1 to 5 substituents independently selected from the group consisting of an aryl optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a C1-6 alkoxy and —NR10R11, a halogen, a hydroxy group, a C1-6 alkyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a C1-6 alkoxy and —NR10R11, a C1-6 alkoxy optionally substituted with 1 to 5 substituents independently selected from the group consisting of a C3-6 cycloalkyl, a C3-6 cycloalkyl-C1-6 alkyl, a C1-6 alkoxy and a fluorine atom, a C1-6 alkylcarbonyl, and —NR10R11, provided that (1) R3A and R3B may be taken together to form a 4- to 10-membered saturated heterocycle optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy and —NR10R11, (2) only one of R3A and R3B can be a hydrogen atom, and (3) R4 is not a hydrogen atom,
• R6 to R11, R6′ and R7′ are the same or different and are a hydrogen atom or a C1-6 alkyl optionally substituted with 1 to 5 fluorine atoms, provided that in each combination of R6-R7, R6′-R7′, R8-R9, and R10-R11, (1) when one is a hydrogen atom, the other one is not a hydrogen atom, and (2) each combination may be taken together to form a 4- to 10-membered saturated heterocycle optionally substituted with 1 to 5 substituents independently selected from the group consisting of a fluorine atom, a hydroxy group, a C1-6 alkyl, a C1-6 alkoxy and —NR6R7, and
• n is 1.