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US 9,309,215 B2Granted
Chiral intermediate, process for producing the same and its use in the manufacture of tolterodine, fesoterodine, or the active metabolite thereof
AssigneeUCB Pharma S.A.
InventorClaus Meese
Life of this patent
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Abstract
The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C1-C6 alkyl. This compound is a valuable intermediate which may be used in the synthesis of fesoterodine, tolterodine, its active metabolite, and related compounds.
Claims12
A process for producing a compound of formula (I)
- wherein a compound of formula (IV)
- is subjected to a reduction reaction with lithium tri(tert-butoxy)aluminium hydride or a dialkylaluminium hydride;
- wherein R represents a straight or branched C1-C6 alkyl group.
A process for producing the active metabolite of tolterodine or phenolic monoesters of formula (III):
- wherein R1 is selected from the group consisting of hydrogen, an optionally substituted straight, branched or cyclic C1-C6 alkyl group and an optionally substituted aryl group, or a salt thereof,
- comprising the step of subjecting a compound of formula (IV)
- to a reduction reaction with lithium tri(tert-butoxy)aluminium hydride or a dialkylaluminium hydride;
- wherein R represents a straight or branched C1-C6 alkyl group, to produce a compound of formula (I)
1 more element
Dependencies are inferred from the claim text.